Senior Scientist – Protein and Structural Chemistry – Discovery Chemistry

Senior Scientist – Protein and Structural Chemistry – Discovery Chemistry

Requirements

• Ph.D. in structural biology, biochemistry, or related field.
• Demonstrated experience in a broad range of activities for atomic resolution single particle Cryo-EM, including sample preparation, data collection, image processing and structure determination.
• Demonstrated experience in a broad range of activities for X-ray crystallography, including crystallization screening and optimization, crystal harvesting, data collection, and structure determination.
• Excellent written and oral communication skills to facilitate team progress and ensure clarity on program status for therapeutic team and management is required.
• Demonstrated strong organizational abilities with a proven track record of managing timeline effectively.
• Ability to prepare and publish peer-reviewed research.

Responsibilities

• Responsible for all aspects of the experimental process from sample preparation and data collection through data processing, structure determination and the effective communication of structural analyses with key stakeholders.
• Active interaction with the external scientific community, including presentations at external meetings.

Preferred Qualifications

• Experience with structure determination of small molecule-protein complexes and multi-subunit protein complexes.
• Experience with micro-electron diffraction.
• Characterization of drug formulations (e.g. VLPs/liposomes/LNPs) by electron microscopy.
• Knowledge of current biophysical and functional characterization methods (e.g. SPR, thermal shift, ligand-binding, and calorimetric assays) to guide construct design and optimization.
• Experience using computational tools for protein engineering and design.
• Experience with scientific programming (e.g. Python) and interest in the application of computational tools to answer structural biology questions.