Senior Scientist/Principal Scientist Renal Biology/ Therapeutic Discovery
| Company | Zoetis |
|---|---|
| Location | Kalamazoo, MI, USA |
| Salary | $Not Provided – $Not Provided |
| Type | Full-Time |
| Degrees | Master’s, PhD |
| Experience Level | Senior, Expert or higher |
Requirements
- PhD, DVM/PhD, or equivalent in renal physiology, molecular biology, pharmacology, biomedical sciences, or a related field. Masters degree with extensive experience will also be considered.
- Strong expertise in renal cell biology, kidney disease mechanisms, and therapeutic development.
- Experience with cell-based assays, organoid models, omics technologies (genomics, transcriptomics, proteomics), and bioinformatics.
- Hands-on experience with CRISPR gene editing, RNA-based therapeutics, or high-throughput screening is a plus.
- Strong communication and teamwork skills, with experience in cross-disciplinary collaborations.
Responsibilities
- Conduct mechanistic research on renal diseases, including chronic kidney disease (CKD), and acute kidney injury (AKI).
- Design and execute in vitro and in vivo models to study renal function, injury, and repair mechanisms.
- Apply in vitro (cell-based, organoid) and in vivo (genetically modified, inducible disease models) systems for target validation and therapeutic evaluation.
- Identify and validate novel therapeutic targets using genomics, proteomics, and functional screening approaches.
- Conduct high-throughput screening (HTS) and assay development for target modulation and lead compound characterization.
- Working with other cross-functional teams, develop and assess small molecules, biologics and other novel therapies for renal disorders in cats and dogs.
- Collaborate with cross-functional teams, including medicinal chemists, protein engineers, pharmacologists, clinicians, and regulatory specialists, to advance drug development programs.
- Analyze and interpret experimental data, prepare technical reports, and contribute to regulatory submissions.
- Stay up to date with emerging research in renal pathobiology, drug discovery, and precision medicine.
Preferred Qualifications
- Prior experience (>2 years) in biotech, pharmaceutical R&D, or translational medicine is desirable.
- Hand on experience in fibrosis biology, inflammation, or renal regenerative medicine.
- Track record of publications and/or patents in the renal biology/therapeutics area.
- Board certification in nephrology.