Senior Scientist – Immunohistochemistry – Ihc – Translational Pathology

Senior Scientist – Immunohistochemistry – Ihc – Translational Pathology

Requirements

• Bachelor’s Degree with 8+ years of academic and/or industry experience, or Master’s Degree with 6+ years of academic and/or industry experience, or Ph.D. or equivalent advanced degree in the Life Sciences with 3+ years of academic and/or industry experience
• Extensive experience in IHC assay development and validation, including antibody screening, chromogenic and multiplexed immunofluorescence assays, digital pathology/image analysis, and novel tissue-based technologies
• Working knowledge of histology/morphology/pathology and data interpretation
• Excellent verbal and written communication skills
• Ability to work flexibly in a matrixed, fast-paced environment as a team player
• Solid problem-solving abilities, excellent organizational skills, attention to detail, and a commitment to excellence

Responsibilities

• Lead IHC projects to meet project requirements in a timely manner
• Responsible for all aspects of assay development and staining including intake, research, planning, development, coordination, execution, risk communication/management, updates and transfer of assays including (but not limited to) chromogenic immunohistochemistry (IHC), in-situ nucleic acid hybridization, multiplexed immunofluorescence (mIF) and digital pathology
• Design, organization, and execution of assay development workflow strategies (feasibility, verification, and validation), with appropriate knowledge and use of controls and test tissues
• Review and score project slides with the engagement of pathologist oversight and review as needed
• Perform image analysis by using Halo software to provide digital quantitative data
• Generate, analyze, summarize, report and interpret IHC data
• Work with In vivo pharmacology teams to advise on preclinical models and study design parameters
• Effectively collaborate in a highly matrixed organization
• Train team members in established methodologies, troubleshoot, and provide guidance to internal collaborators
• Work flexibly in a fast-paced industrial research environment as a team player
• Maintain workplace and lab compliant processes, documentation, and communication
• This is a lab-based position requiring on-site work >80% of the time (averaged across 2 weeks)

Preferred Qualifications

• PhD degree in biological sciences or related biomedical fields with over 3 years of relevant experience in industry or academic pathology lab setting
• Prior experience in oncology/immuno-oncology and biotech/biopharmaceutical industry is highly preferred
• Thorough knowledge and extensive hands-on experience in IHC antibody selection, screening, validation, IHC assay development, multiplexed immunofluorescent, in situ hybridization/RNAscope staining are required
• Experience in Leica, Ventana, Dako, Phenocycler and Xenium platforms is preferred
• Knowledge of histology and pathology is required. Should be comfortable working with pathologists in designing and interpreting pathobiology research
• Experience with digital scanning, image management systems (IMS), and digital image analysis platforms (HALO, Visiopharm) for H&E, immunohistochemical and multiplexed fluorescence images is required
• Excellent organizational and communication skills in written and verbal English
• Collaborative/team spirit and ability to thrive in a matrixed environment, familiarity with a fast-paced work environment
• Self-motivated and eager to learn new skills and technologies