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Senior Scientist I – Antibody & Protein Characterization
| Company | Exelixis |
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| Location | Alameda, CA, USA |
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| Salary | $116000 – $165500 |
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| Type | Full-Time |
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| Degrees | Master’s, PhD |
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| Experience Level | Senior |
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Requirements
- Ph.D. in a relevant scientific discipline such as molecular biology, biochemistry, biology or microbiology with zero (0) or more years of experience in the biotechnology/pharmaceutical industry; or,
- Master’s degree in a relevant scientific discipline such as molecular biology, biochemistry, biology or microbiology and a minimum of five (5) years of experience in the biotechnology/pharmaceutical industry; or,
- Equivalent combination of education and experience.
- Experience and knowledge in assay development for protein characterization techniques including, but not limited to, chromatographic methods (SEC-HPLC, HIC-HPLC, RP-HPLC), mass spectrometric methods (intact mass, subunit mass, peptide mapping), affinity measurements (SPR, BLI), and biophysical characterization (DSF, SLS, DSF, cIEF).
- Hands on laboratory experience in general protein and antibody characterization (SDS-PAGE, Western Blot, etc.).
- Experience writing summaries, reports, presenting scientific data/results to internal and external collaborators.
- Experience with state-of-the art technologies to support ongoing protein/antibody characterization needs.
- Experienced in the purification of proteins and antibodies using various modes of chromatography (affinity, size-exclusion, ion-exchange and HIC) is a plus.
Responsibilities
- Characterize the identity, purity, biochemical and biophysical attributes of recombinant antibodies and proteins to support the group’s discovery prioritization and preclinical development efforts.
- Provide scientific input on protein science activities (upstream, downstream, characterization) on cross-functional teams to support the discovery and preclinical development of biotherapeutic candidates.
- Play a key role in assessing protein structure/function during discovery efforts as well as analytical development as applied toward the evaluation of biologics for developability and large-scale manufacturing.
- Comply with company health and safety policies and general laboratory practices (including documentation, i.e., ELN).
Preferred Qualifications
- Familiarity with general components of biologics CMC is a plus.
