Senior Scientist – Dmpk
| Company | Korro Bio |
|---|---|
| Location | Cambridge, MA, USA |
| Salary | $Not Provided – $Not Provided |
| Type | Full-Time |
| Degrees | Bachelor’s, Master’s, PhD |
| Experience Level | Senior, Expert or higher |
Requirements
- Degree in pharmaceutical sciences, analytical chemistry, molecular biology or related discipline. BS or MS with at least 8 years of experience in the pharmaceutical industry or PhD with at least 4 years of experience working with bioanalysis of oligonucleotide therapeutics.
- Hands on-assay development experience with different bioanalytical assay formats and broad in-depth knowledge of regulatory requirements.
- Strong assay troubleshooting, data analysis and interpretation skills.
- Knowledge and experienced in bioanalysis within ADME/DMPK, metabolite identification, biodistribution and how DMPK fits into the larger picture of drug discovery and development.
- Experience conducting cellular assays with cell culture.
- Relevant project representation experience in cross-collaborative program teams as a DMPK expert.
- Excellent interpersonal and communication skills in a variety of settings, ability to share and discuss scientific data clearly to peers and to senior leadership.
- Team oriented and collaborative approach to work across multiple teams.
- Attention to detail, critical analysis of data/reports, and troubleshooting abilities.
- Proven ability to achieve results, keep projects on timeline, and find solutions as needed to ensure that project deliverables are met.
Responsibilities
- Contribute to the bioanalytical and biotransformation strategy.
- Design, plan, and execute assays to understand the biodistribution, pharmacokinetic and metabolic properties of novel ONTs with multiple mechanisms of delivery.
- Be proficient in ligand binding assays, LC-MS/MS, HRAM and automation platforms.
- Actively keep up to date with the ongoing research in the field and apply novel assays to achieve goals related to building DMPK understanding from Research through Development.
- Cross-functional collaboration with Biology, Delivery, Chemistry, and In Vitro and In Vivo Pre-clinical Pharmacology teams to advance Korro Bio’s early research activities to preclinical development.
- Independently run laboratory experiments to support and advance discovery efforts.
- Mentor and train junior scientists.
- Multi-task across several projects and manage time effectively to achieve results.
- Design and write protocols, perform experiments, organize and analyze data, interpret results, record experiments in an electronic lab notebook, and summarize work in presentations and technical reports.
- Adhere to all laboratory safety requirements and standard operating procedures, help maintaining general laboratory functionality, including lab equipment maintenance and the ordering, and receiving of lab supplies.
- Other duties as assigned.
Preferred Qualifications
- Experience managing direct reports and CRO resources is a plus.