Senior Principal Scientist – In Vivo Pharmacology – Oncology Discovery Biology
| Company | Bristol Myers Squibb |
|---|---|
| Location | Cambridge, MA, USA |
| Salary | $Not Provided – $Not Provided |
| Type | Full-Time |
| Degrees | Bachelor’s, Master’s, PhD |
| Experience Level | Senior, Expert or higher |
Requirements
- Bachelor’s Degree + 10+ years of academic and / or industry experience
- Master’s Degree + 8+ years of academic and / or industry experience
- Ph.D. or equivalent advanced degree in the Life Sciences + 6+ years of academic and / or industry experience
- 2+ years of leadership experience
Responsibilities
- Function as Pharmacology lead for multiple T cell engager drug discovery programs.
- Characterize therapeutic candidates in vivo as part of the lead selection process.
- Identify and develop state of the art in vivo models, experimental protocols and relevant IO assays.
- Working with cross-functional teams participate in development and implementation of program strategy.
- Design, execute and deliver experiments comprehensive high quality data sets to drive decision making.
- Communicate program strategy and timelines to management.
- Manage a team of in vivo scientists providing guidance and mentoring to junior level scientists and Research associates.
- Leads initiatives related to development of new approaches / technologies within T-Cell engager strategy.
Preferred Qualifications
- PhD immunology, cancer biology or relevant biological science with 6-8 years of relevant industry experience in in vivo pharmacology and a deep expertise in T cell biology and immune-oncology.
- Industry experience with a proven track record of independently driving in vivo strategy for immune cell engagers, including CD3 T cell engagers.
- Demonstrated ability to independently develop focused in vivo strategies and utilizing PK/PD/efficacy data to drive discovery, optimization, and characterization of CD3 T-cell engagers is required.
- Demonstrated leadership in developing and deploying novel in vivo models to enable immune cell engager, including T-cell engagers, drug discovery and translational research is required.
- Experience using various cell line and PDX mouse models, humanized mouse models, admixture xenografts, orthotopic models to build in vivo strategies to enable candidate selection for early clinical development is highly desired.
- Demonstrated expertise in utilizing relevant pharmacodynamic assays such as MSD ELISAs, immune profiling by flow cytometry, Luminex.
- Track record of building high functioning teams, managing and mentoring scientists in laboratory-based roles to support preclinical discovery research programs.