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Scientist III – Lead Discovery
| Company | Exelixis |
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| Location | Alameda, CA, USA |
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| Salary | $89500 – $127500 |
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| Type | Full-Time |
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| Degrees | Bachelor’s, Associate’s |
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| Experience Level | Mid Level, Senior |
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Requirements
- Bachelor’s degree in related discipline + three years of related experience; or
- Associate’s degree in related discipline + five years of related experience
- High School Diploma/GED + seven years of related experience
- Equivalent combination of education and experience.
- Hands-on experience with a variety of biophysical and biochemical assay technologies relevant to small molecule drug discovery is required
- Thorough knowledge of and experience with surface plasmon resonance (SPR) techniques to discover and characterize small molecule-protein target complexes is highly desired
- Hands-on experience with a variety of laboratory automation equipment (e.g. liquid handlers, dispensers, readers) is a strong plus
Responsibilities
- Develops, optimizes, and executes small molecule compound profiling and HTS biochemical and biophysical assays
- Contributes to the design, planning, and execution of HTS campaigns and mechanism of action (MoA) studies
- Evaluates and implements new protocols and workflows to support projects from hit finding, hit validation, to lead optimization stages
- Presents data and reports on project status to department head/manager and at discovery project and research meetings
- Communicates scientific results to manager, department, and project team partners and/or collaborators
- Maintains laboratory notebook in a complete, consistent, and concise manner in accordance with company intellectual property policies and practices
- Complies with company health and safety policies and general laboratory practices
- Other responsibilities, as assigned
Preferred Qualifications
- Broad understanding of biophysical (SPR, MST, NanoDSF, BLI, thermal shift assays, etc.) and biochemical assays (HTRF, AlphaLisa, Lumit, MSD, ELISA, FP, GLO, etc.)
- Remains current with relevant scientific literature and advancements in lab technologies and new drug discovery technologies/methodologies and suggests their implementation
- In discussion with manager, sets goals with understanding of priority and impact to projects, the department, and organization. Solid understanding of how individual experiments fit within a larger discovery project
- Ability to collaborate with a cross-functional team on extremely complex problems
- Ability to multi-task in a fast-paced dynamic environment while delivering high-quality work
- Excellent interpersonal and written communication skills
