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Scientist I – Preclinical Development

Scientist I – Preclinical Development

CompanyArsenalBio
LocationSan Bruno, CA, USA
Salary$113600 – $139100
TypeFull-Time
DegreesBachelor’s, Master’s, PhD
Experience LevelJunior, Mid Level

Requirements

  • PhD in Cell or Molecular Biology, Biological Sciences, or a related field with up to 2 years of relevant experience; OR a Master’s degree in these fields with at least 5 years of industry experience; OR a Bachelor’s degree in a related field with at least 7 years of industry experience
  • Excellent mammalian cell culture skills
  • Experience with multi-color flow cytometry, panel design, and data analysis
  • Ability to quickly adapt and learn new skills for changing research priorities
  • Demonstrated ability to work as a team player in a collaborative environment and coordinate tasks across multiple projects to meet deadlines
  • Strong organizational skills, record-keeping, and interpersonal communication skills (verbal and written)
  • Growth Mindset with the ability to think outside the box, a creative approach to problem-solving
  • Willingness to accept responsibilities outside of the initial job description
  • Passionate drive to accomplish work with a positive attitude

Responsibilities

  • Independently plan, execute, analyze, and report on experiments to support the preclinical development of novel T-cell therapy products across multiple pipeline programs
  • Perform in vitro cell-based functional assays (cytotoxicity, cytokine, proliferation, etc.) for CAR T cell therapeutic candidate selection
  • Design, execute, and analyze flow cytometry experiments for CAR T cell product characterization
  • Support engineered T cell production activities (e.x. gene editing, T cell culture, cryopreservation, cell thawing)
  • Culture both engineered primary T cell and suspension/adherent cell lines
  • Support IND-enabling preclinical studies
  • Assist effectively with cross-functional activities for project teams, including hand-offs, data analysis, and presenting at project meetings
  • Maintain an up-to-date and detailed electronic lab notebook

Preferred Qualifications

  • Experience with primary T cell culture
  • Experience with CRISPR gene editing and cell engineering workflows
  • Experience with Incucyte live cell imager
  • Experience with semi-automated pipetting workflows (e.x. Integra VIAFLO)
  • Experience mentoring/supervising junior research technicians
  • Knowledge of CAR T cell therapy