Skip to content
Scientist – Cell Line Development
| Company | Sanofi |
|---|
| Location | Framingham, MA, USA |
|---|
| Salary | $100500 – $145166.66 |
|---|
| Type | Full-Time |
|---|
| Degrees | Master’s, PhD |
|---|
| Experience Level | Mid Level, Senior |
|---|
Requirements
- PhD (plus 1-2 yr experience) in Biology, Cell Biology, Molecular Biology, Bioengineering, or related discipline, or Master’s degree in relevant discipline with >4yr of relevant experience.
- Hands-on experience in mammalian cell line development in a pharmaceutical or biotechnology setting.
- Experience using automation platforms is highly desirable (Beckman, Tecan, Hamilton, Beacon, VIPS, etc.).
- Strong technical background and attention to detail.
- Self-motivated with excellent communication, organization and time-management skills.
- Demonstrated ability to work independently and in a highly collaborative environment and adhere to timelines.
Responsibilities
- Technical oversight and delivery of end-to-end cell line development work packages (as CLD Lead & Operator) to meet deliverables for preclinical and clinical development projects, including reports and presentations to stakeholders.
- Perform cell culture techniques for both pool and clone generation of expressive populations.
- Actively engage and contribute to optimize cell line generation process towards using an automation-enabled high-throughput cell line platform.
- Represent the CLD function on project teams and within Global CMC, making decisions for cell line activities and effectively communicating results, progress and plans. Active engagement and collaboration with global DS teams as the CLD representative.
- Drive innovation strategies for generating cell lines, to ensure ‘right first time’ delivery of commercial-ready cell lines.
- Active engagement with Research functions ensuring smooth transition of projects and data.
- Compliance with all applicable regulations, ensure that work performed is conducted in a safe and compliant manner, ensure maintenance of proper records in accordance with SOPs and policies.
- Prepare and review documentation for regulatory submissions.
Preferred Qualifications
- Suspension mammalian cell culture experience (CHO cell culture) in a pharmaceutical or biotechnology setting.
- Experience with automation and/or high throughput technologies as applied to mammalian cell line generation and process optimization is highly preferred.
- Experience in mammalian gene expression systems, gene editing and/or ‘omics technologies, experience in genetic characterization of cell lines, gene expression optimization.
- Deep working knowledge in the technical and quality CMC requirements for cell line development, and overall CMC space.
- Experience and working knowledge in high-throughput screening tools (bioreactors, analytics) for cell line selection.
- Flexibility and a willingness to expand skill set and responsibilities, and excel in a past-paced highly cooperative team environment, ability to multitask, adaptability and positive attitude.
- Experience leading projects, preparing regulatory submissions.
- Experience with genetic characterization (gene copy number, transcript analysis) and CLD regulatory experience.
