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Principal Scientist – Research Science – Genomics
| Company | Merck |
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| Location | Linden, NJ, USA |
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| Salary | $153800 – $242200 |
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| Type | Full-Time |
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| Degrees | PhD, MD |
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| Experience Level | Expert or higher |
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Requirements
- Ph.D., MD or MD/PhD in a life sciences discipline (Biochemistry, Immunology, Genetics, Molecular Pathology, Cell Biology, etc.) or Chemistry
- A minimum of 10 years of pharmaceutical or related experience
- A minimum of 5 years of industry experience in Genomics
- 3+ years of research experience is required with an MD
- Experience leading liquid biopsy (e.g. cfDNA, cfDNA, ctDNA, utDNA, cfDNA methylation, etc.), biomarker research, assay development and validation
- A combination of experience with various NGS platforms, qPCR, digital PCR, and other genetic/genomic assay platforms
- Understanding of standards and guidelines for analytical method validation
- Strong record of scientific achievement (publications, patents, internal/external scientific/technical presentations, etc.)
- Strong interpersonal, verbal and written communication skills
- Able to work independently, represent TMB Genomics on multiple projects
- Strong leadership skills
- Ability to execute within a matrixed organization
Responsibilities
- Serve as a subject matter expert in the development and validation of genomics assays collaborating with clinical and biomarker leaders, as well as operations teams, biostatistics, companion diagnostics (CDx), and regulatory affairs.
- Interface with scientists in Discovery and Clinical development to strategically plan, execute and interpret genomics results from biomarker analyses, ensuring accurate conclusions are drawn.
- Execute and coordinate the development and fit-for-purpose validation of assays within TMB Genomics lab labs.
- Execute and coordinate the analysis of clinical samples.
- Identify and assess emerging genomics technologies and validate those that have use within a clinical trial setting.
- Collaborate and liaise with external partners and Contract Research Organization (CROs) to manage the development, validation and execution of genomics assays to support all therapeutic areas.
- Write memos, final reports and publications summarizing data and present findings to clinical and other internal stakeholders.
Preferred Qualifications
- Precision medicine expertise in Oncology and/or Immunology fields
- Broad knowledge of drug development process and translational medicine
- Experience with the design and development of Minimal Residual Disease (MRD) assays, TCR/BCR repertoire sequencing and analysis is advantageous
- Molecular Genetic Pathology or Laboratory Medicine training
