Principal Scientist – Antibody-Drug Conjugate Chemistry
| Company | Exelixis |
|---|---|
| Location | Alameda, CA, USA |
| Salary | $140000 – $198000 |
| Type | Full-Time |
| Degrees | Bachelor’s, Master’s, PhD |
| Experience Level | Senior, Expert or higher |
Requirements
- Bachelor’s degree in related scientific discipline such as synthetic chemistry, organic chemistry, medicinal chemistry or bioconjugation and a minimum of eleven years of experience in the biotechnology/pharmaceutical industry
- Master’s degree in related scientific discipline such as synthetic chemistry, organic chemistry, medicinal chemistry or bioconjugation and a minimum of nine years of experience in the biotechnology/pharmaceutical industry
- PhD degree in related scientific discipline such as synthetic chemistry, organic chemistry, medicinal chemistry or bioconjugation and a minimum of five years of experience in the biotechnology/pharmaceutical industry
- Hands on laboratory experience in medicinal discovery including critical reagent generation, identification and optimization of small molecule, payloads, and drug-linkers
- Hands on laboratory experience in small molecule characterization
- Experience in a variety of analytical instruments and technologies including HPLC, LC/MS, NMR to enable structural determination and purity assessment
- Experience writing summaries, reports, presenting scientific data/results to internal and external collaborators
Responsibilities
- Design, synthesis, purification, and characterization of small molecule lead compounds
- Troubleshoot and optimize multi-step synthetic routes
- Provide ADC expertise in state-of-the-art ADC technologies including linkers, payloads and bring novel ideas to POC
- Interact and collaborate with internal departments and external colleagues to discuss and resolve project needs and issues in research and early development of ADCs
- Provide support in evaluation of ADC research platforms and preclinical licensing candidates as needed
- Provide critical scientific/technical data analysis, interpretation of experiments and report writing
- Effectively communicate scientific concepts, study findings and interpretations to multi-disciplinary teams
- Interact and collaborate with internal departments to deliver quality and timely findings in support of drug candidate advancement
- Work externally facing with development partners to implement joint research projects, including presentation of findings and experimental data at scientific meetings
- Follow company intellectual property and compliance policies and practices
- Comply with company health and safety policies and general laboratory practices
Preferred Qualifications
- Experience in bioconjugation
- Familiarity with general components of bioconjugation and ADC