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Postdoctoral Fellow – Respiratory & Immunology – Early Discovery Research
| Company | AstraZeneca |
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| Location | Gaithersburg, MD, USA |
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| Salary | $99900 – $107500 |
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| Type | Full-Time |
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| Degrees | PhD |
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| Experience Level | Mid Level |
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Requirements
- PhD in Immunology, Biochemistry, Molecular Biology or related field
- A maximum of 4 years of postdoctoral experience
- Effective implementation of standard immunology and molecular biology lab assays and in vitro cell culture to answer research questions
- Extensive knowledge of innate immunity mechanisms and other immunology mechanisms
- Publication record of novel and impactful research
Responsibilities
- Employ established methodologies to generate a comprehensive macrophage secretome by co-culturing apoptotic cells and macrophages
- Collaborate with omics groups to profile the secretome (proteome and lipidome) and transcriptome of macrophages post-efferocytosis
- Work with the bioinformatics team to analyze data and identify novel activators and signaling changes in the macrophage secretome
- Verify the effects of the secretome and identified activators on immune mechanisms, signaling pathways, and cell functions using established immune cell assays
- Explore the potential of engineering pre-resolved macrophages and test cell therapy opportunities in an in-vivo pilot study
Preferred Qualifications
- Background in inflammation research (lipid mediators, resolution processes) with a basic understanding of autoimmune disease biology, including cell types, signaling pathways, lipid mediators, and mechanisms
- Experience with more complex culture models such as cell co-cultures, organoids, and sample preparation for lipidomics, proteomics, and RNA sequencing
- Previous experience with RNA sequencing, proteomics, and lipidomics techniques
- Previous experience with data science/bioinformatics and the analysis of large and complex data sets
