Effector Function Scientist - Protein Therapeutics

Effector Function Scientist – Protein Therapeutics

B.S. (with 3-6 years experience) or M.S (with 2-4 years experience) with an emphasis in Immunology, Cell biology, Molecular biology or related field
Excellent communication, organizational and interpersonal skills
Solid understanding of immunology, monoclonal antibody therapeutics, Fc effector function, antibody/protein binding kinetics, flow cytometry, cell imaging techniques and parasitology

Design, conduct and interpret data from cell-based effector function assays (CDC, ADCP and ADCC) for veterinary species of interest
Design, conduct and interpret data from antibody/protein binding kinetic assays using SPR, mainly Biacore
Design and development of cell-based assays using cell imaging techniques
Design and development of whole blood flow cytometry assays
Design and development of cell-based assays supporting heartworm target projects
Collaborate with and support research teams, CROs and project teams for successful completion of cell-based and SPR assays
Record experiments and data appropriately and author technical reports
Keep abreast of relevant new technologies & relevant literature
Ensure work activities are aligned with data acquisition, notebook entry and EHS requirements.

Extensive experience with cell culture of both cell lines and primary cells, with a strong preference for experience with veterinary species
Knowledge and working experience handling antibody samples
Experience with cell killing assays
Experience with Incucyte live-cell real-time imaging system
Basic experience with Biacore SPR instrument
Ability to independently contribute from the bench
Ability to design and execute various cell-based assays and data analysis/interpretation
Good oral and written communication skills
Must be highly motivated. The ability to take direction and work simultaneously on multiple projects is essential.