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Director Protein Engineering & Novel Modalities
| Company | AstraZeneca |
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| Location | Gaithersburg, MD, USA |
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| Salary | $172672 – $259008 |
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| Type | Full-Time |
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| Degrees | PhD |
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| Experience Level | Expert or higher |
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Requirements
- Ph.D in Biotechnology, Biochemistry, Molecular Biology or other relevant scientific field with 10+ years of experience in antibody engineering and/or bispecific antibody technologies in the Biotech or Biopharmaceutical industry
- Proven record in antibody drug development and driving bispecific programs from early discovery into development stage
- Proven ability to lead a team, setting goals and objectives, motivate and develop others and influence recruitment of high performing staff
- Extensive hands-on experience in molecular biology, antibody design and engineering and characterization of various bispecific antibody formats
- Demonstrated ability to influence and build strong relationships with internal and external collaborators while working effectively in a collaborative team environment across multiple functions
- Track record of problem solving, risk management, negotiating and influencing skills
- Strong industry leadership experience, excellent written and verbal communication skills and effective presentation of complex scientific reports to cross-functional and senior management teams are essential for this role.
Responsibilities
- Lead and expand a team of scientists to advance innovative bispecific technologies and support bispecific pipeline progression.
- Collaborate and work closely with scientific leads across all therapeutic areas to ensure timely progress of pipeline projects and drive technological innovations.
- Direct and progress bispecific programs from early discovery to development stage.
- Establish high-level of scientific innovation and develop bispecific technologies for enhanced selectivity, improved developability, and reduced off-target and off-organ toxicities to ensure scientific excellence and effective achievement of research goals.
- Track record of scientific innovation as evidenced by strong scientific publications, inventorship on patents and presentations at major conferences.
Preferred Qualifications
- Strong background in immunology, T cell biology and cancer biology.
- Strong experience in structure/function-based techniques, including crystallography, Cryo EM.
- Deep understanding of various imaging/multicolor flow cytometry-based instruments and data analysis programs.
- Experience in antibody discovery using one of several display-based technologies is preferred but not essential.
- Experience in development of in vivo mouse models and subsequent analysis for efficacy and PK.
