Director – Drug Metabolism – Biotransformation
| Company | Gilead Sciences |
|---|---|
| Location | San Mateo, CA, USA |
| Salary | $226185 – $292710 |
| Type | Full-Time |
| Degrees | Bachelor’s, Master’s, PhD |
| Experience Level | Senior, Expert or higher |
Requirements
- Bachelor’s Degree and Twelve Years’ Experience
- OR
- Masters’ Degree and Ten Years’ Experience
- OR
- PhD and Eight Years’ Experience
Responsibilities
- Work closely with internal and external resources to assure high quality and timely delivery of nonclinical and clinical biotransformation data for molecules in discovery and development, including 14C mass balance studies.
- Design and perform complex analyses to characterize biotransformation and disposition of candidate drugs.
- Serve as a drug metabolism and biotransformation subject matter expert for multiple dynamic cross-functional teams, to define strategies to achieve target product profiles, integrate in vitro and in vivo drug disposition data, interpretation, and give presentations to teams.
- Provide clear verbal communication of results and strategies at group, department, project team and management level. Write research reports and regulatory documents.
- Contribute to science through conference presentations and publication of new findings.
Preferred Qualifications
- A highly motivated individual with PhD degree in life sciences with 8 – 10 years of post-doctoral and/or industry experience directly related to the Specific Responsibilities listed above (hands-on experience and deep knowledge of biotransformation and structure elucidation).
- Considered an expert in metabolic routes of biotransformation and metabolite identification demonstrated through presentation/publication.
- Comfortable working with and educating colleagues in drug metabolism, toxicology and clinical pharmacology departments, on strategies to understand drug metabolism and disposition.
- Demonstrates excellent scientific verbal and technical communication, and interpersonal skills. Must be organized, pay attention to details and have strong organizational and planning skills.
- Expertise and experience in one or more of the following areas: Lead design and execution of nonclinical and clinical radio- and non-radiolabeled ADME studies. Serve as an expert resource; to ensure radiochemical design, develop protocols and placement of studies. Provide oversight and integration of the data and data reports. Proactively manage resolution of data gaps. Ensure reports are written to communicate clear messages and are ready for regulatory submissions. State of the art bioanalysis by LC/MS, F-NMR and related techniques.