Director – Drug Metabolism

Director – Drug Metabolism

Requirements

• Bachelor’s Degree and Twelve Years’ Experience
• Masters’ Degree and Ten Years’ Experience
• PhD and Eight Years’ Experience
• Hands-on experience and deep knowledge of enzymology and enzyme kinetics.

Responsibilities

• Conduct studies to determine the kinetics of metabolism of drug candidates and the roles of various enzymes in the metabolic profiles of those compounds.
• Serve as a drug metabolism and enzyme kinetics subject matter expert for multiple dynamic cross-functional teams.
• Work closely with internal and external resources to assure timely delivery of high-quality data.
• Provide clear verbal communication of results and strategies at group, department, project team and management level.
• Write research reports and regulatory documents.
• Contribute to science through conference presentations and publication of new findings.

Preferred Qualifications

• A highly motivated individual with PhD degree in life sciences with 8 – 10 years of post-doctoral and/or industry experience directly related to the Specific Responsibilities listed above.
• Hands-on experience in application of the enzymology data in physiologically-based PK (PBPK) modeling (using e.g. Simcyp, GastroPlus or custom models).
• Demonstrates excellent scientific verbal and technical communication, and interpersonal skills.
• Expertise and experience in one or more of the following areas: Experience in drug development, authoring documents for regulatory authorities, deep understanding of the principles, theories and approaches of PK, drug disposition and drug interactions, proven application of modeling methods for quantitative translation using Simcyp, GastroPlus and/or general kinetic modeling programs, state of the art bioanalysis by LC/MS and related techniques.