Director – Dmpk
| Company | Valo Health |
|---|---|
| Location | Lexington, MA, USA |
| Salary | $Not Provided – $Not Provided |
| Type | Full-Time |
| Degrees | Bachelor’s, Master’s, PhD |
| Experience Level | Expert or higher |
Requirements
- Broad DMPK experience and expertise spanning target assessment to clinical development, with an awareness of regulatory guidance and industry trends.
- Ability to effectively communicate, influence and lead in a matrix environment.
- Ph.D. in a relevant scientific discipline and 10+ years of drug discovery experience or BS/MS and 15+ years.
Responsibilities
- Work closely with a team of experienced drug hunters to create novel, differentiated drug candidates, by providing strategic guidance and execution associated with in vitro and in vivo profiling, IVIV correlation and extrapolation, PK/PD/Effect relationship development, and human dose projection to move programs from target concept to the clinic.
- Partner closely with a team of AI/ML and data scientists to develop and implement a comprehensive and robust platform for in silico prediction of complex PK/ADME properties.
- Identify, qualify, engage, and manage external providers of in vitro ADME and in vivo PK services; analyze and interpret resulting data.
- Together with in vitro ADME leadership, drive a cross-functional strategy aimed at capability refinement and expansion to address growing portfolio needs.
Preferred Qualifications
- Leading-edge mindset in relation to current experimental and computational DMPK approaches and techniques. Modeling and simulation expertise preferred.
- Track record of success rapidly identifying and advancing preclinical development candidates through appropriate stage gates, enabling key go/no go decisions.
- Small molecule drug development experience across multiple indications. Experience in Cardiovascular, Obesity and CNS indications, as well as grounding across multiple modalities, a plus.