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Clinical Genomics Scientist – Oncology
| Company | BillionToOne |
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| Location | Menlo Park, CA, USA |
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| Salary | $156060 – $176868 |
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| Type | Full-Time |
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| Degrees | Master’s, PhD |
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| Experience Level | Mid Level |
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Requirements
- Ph.D. in Human Genetics, M.S. in Genetic Counseling, or related field
- 2+ years of experience in somatic variant interpretation based on ACMG/AMP guidelines in a clinical setting (alternatively, 1+ years of germline variant interpretation *and* 1+ years of somatic variant interpretation experience)
- Hands-on experience working with human mutation databases (COSMIC, ClinVar, OncoKB), functional annotation sources (dbSNP), and genome browsers (UCSC)
- Familiarity with IGV and BAM file analysis and data-minded willingness to learn to use basic bioinformatics tools, with technically minded insights
- Knowledge of cancer somatic mutation and signaling pathways (e.g., which mutations have FDA approved drugs, Phase II/III clinical trials, which mutations are considered “hot targets” for drug development, etc.)
- Exceptional attention to detail to follow highly detailed SOPs and strong organizational skills to track and manage clinical reporting and product improvement projects
- Excellent communication skills and ability to work collaboratively with cross-functional teams
- Operationally-defined flexible schedule, including weekends, as dictated by clinical reporting needs
Responsibilities
- Perform somatic-based variant interpretation, diving into the literature and databases to classify variants and match treatments for reporting, performing verification as required with BAM file analysis.
- Carefully draft reports for each requisition primarily using in-house reporting API, working closely with the engineering and QA teams on reporting, and the laboratory directors on report language.
- Work closely with lab directors, R&D, medical, and other related functions to develop and modify the somatic interpretation SOPs in accordance with ACMG/AMP guidelines, and the latest published literature.
- Contribute to curation of gene-level content such as domain and critical residue curation.
- Serve as a subject matter expert in consulting with the medical science liaison team, and presenting in molecular tumor boards to facilitate knowledge sharing.
- Work closely with the R&D team to help with somatic oncology based projects, providing expertise on variant interpretation, biological pathways/mechanisms, and other gene/variant-level reviews and analyses.
Preferred Qualifications
No preferred qualifications provided.
