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Scientist – Cancer Metabolism

Scientist – Cancer Metabolism

CompanyCalico Labs
LocationSan Bruno, CA, USA
Salary$127000 – $155000
TypeFull-Time
DegreesPhD, MD
Experience LevelMid Level, Senior

Requirements

  • PhD or MD/PhD in cell/molecular biology, biochemistry or a related field with 0-5 years of postdoctoral and/or industry experience
  • Experience working with animal models to study human disease
  • Deep knowledge of cellular and organismal metabolism and physiology
  • Strong working knowledge of genetics, cell biology and molecular genetics
  • Detail-oriented, organized and driven
  • A track record of strong research productivity
  • Strong teamwork and communication skills
  • Flexible, able to respond quickly to shifting priorities and able to multitask
  • Must be willing to work onsite five days per week

Responsibilities

  • Perform basic research to determine the role of metabolic interactions in tumor progression, metastasis to specific organs and therapy resistance
  • Develop approaches to evaluate metabolic interactions between specific cell types during tumor progression and metastasis
  • Publish papers and present findings both internally and at scientific conferences

Preferred Qualifications

  • Experience with mass spectrometry to measure metabolites and/or lipids and/or proteins
  • Experience using stable isotope labeling to understand metabolic fluxes in vitro and/or in vivo
  • Experience with cancer mouse models
  • Experience with mouse models of brain tumors
  • Experience in pediatric tumor biology
  • Experience with integrating multiomics data
  • Competence with mammalian tissue culture, in vitro gene editing techniques (CRISPR/Cas9, viral transduction) and basic molecular biology methods
  • Familiarity with R or Python for data analysis and visualization